期刊
SCIENCE
卷 351, 期 6271, 页码 397-400出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad7977
关键词
-
资金
- National Basic Research Program of China [2012CBA01300, 2015CB943000, 2014CB542300]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01000000]
- National Natural Science Foundation of China [81490742, 31200879, 31300960, 31300957, 81472181, 31470768, 81321062]
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly from 5' transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications. Injection of sperm tsRNA fractions from HFD males into normal zygotes generated metabolic disorders in the F-1 offspring and altered gene expression of metabolic pathways in early embryos and islets of F-1 offspring, which was unrelated to DNA methylation at CpG-enriched regions. Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerational inheritance of diet-induced metabolic disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据