期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 30, 期 9, 页码 2013-2023出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/mst110
关键词
fascin; choanoflagellate; Capsaspora; Cdc42; formin evolution; gelsolin evolution; filopodia; pseudopodia
资金
- Institucio Catalana de Recerca i Estudis Avancats
- European Research Council [ERC-2007-StG-206883]
- Ministerio de Economia y Competitividad (MINECO) [BFU2011-23434]
- NIH NIGMS [GM089977]
- MICINN
- Deutsche Forschungsgemeinschaft (DFG)
- Canadian Research Chair program grant
- ICREA Funding Source: Custom
Filopodia are fine actin-based cellular projections used for both environmental sensing and cell motility, and they are essential organelles for metazoan cells. In this study, we reconstruct the origin of metazoan filopodia and microvilli. We first report on the evolutionary assembly of the filopodial molecular toolkit and show that homologs of many metazoan filopodial components, including fascin and myosin X, were already present in the unicellular or colonial progenitors of metazoans. Furthermore, we find that the actin crosslinking protein fascin localizes to filopodia-like structures and microvilli in the choanoflagellate Salpingoeca rosetta. In addition, homologs of filopodial genes in the holozoan Capsaspora owczarzaki are upregulated in filopodia-bearing cells relative to those that lack them. Therefore, our findings suggest that proteins essential for metazoan filopodia and microvilli are functionally conserved in unicellular and colonial holozoans and that the last common ancestor of metazoans bore a complex and specific filopodial machinery.
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