期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 30, 期 9, 页码 2113-2120出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/mst111
关键词
association studies; population genetics; behavior; artificial selection; courtship; Drosophila
资金
- University of California Santa Barbara
- National Institute of Health [R01 GM098614]
- National Science Foundation [NSF MRSEC DMR-1121053, NSF CNS-0960316]
Little is currently known about the genetic complexity of quantitative behavioral variation, the types of genes involved, or their effects on intermediate phenotypes. Here, we conduct a genome-wide association study of Drosophila melanogaster courtship song variation using 168 sequenced inbred lines, and fail to find highly significant associations. However, by combining these data with results from a well-powered Evolve and Resequence (E&R) study on the same trait, we provide statistical evidence that some power to associate genotype and phenotype is available. Genes that are significant in both analyses are enriched for expression in the nervous system, and affect neural development and synaptic growth when perturbed. Quantitative complementation at one of these loci, Syntrophin-like 1, supports a hypothesis that variation at this locus affects variation in the inter-pulse interval of courtship song. These results suggest that experimental evolution may provide an approach for genome-scale replication in Drosophila.
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