期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 29, 期 11, 页码 3267-3280出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/mss134
关键词
aging; adult stem cell; self-renewal; differentiation; evolution
资金
- Deutsche Forschungsgemeinschaft [DFG SFB 617-A1]
- DFG Cluster of Excellence programs The Future Ocean and Inflammation at Interfaces
How distinct stem cell populations originate and whether there is a clear stem cell genetic signature remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据