期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 29, 期 11, 页码 3249-3253出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/mss151
关键词
Plasmodium falciparum; natural selection; SNP; genome; West Africa
资金
- Bill and Melinda Gates Foundation
- Ellison Medical Foundation
- ExxonMobil Foundation
- NIH Fogarty
- Broad Institute
- NIAID
- UK Medical Research Council
- NSF
- Medical Research Council [MC_U190081987] Funding Source: researchfish
- MRC [MC_U190081987] Funding Source: UKRI
We used a high-density single-nucleotide polymorphism array to genotype 75 Plasmodium falciparum isolates recently collected from Senegal and The Gambia to search for signals of selection in this malaria endemic region. We found little geographic or temporal stratification of the genetic diversity among the sampled parasites. Through application of the iHS and REHH haplotype-based tests for positive selection, we found evidence of recent selective sweeps at a known drug resistance locus, at several known antigenic loci, and at several genomic regions not previously identified as sites of recent selection. We discuss the value of deep population-specific genomic analyses for identifying selection signals within sampled endemic populations of parasites, which may correspond to local selection pressures such as distinctive therapeutic regimes or mosquito vectors.
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