期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 26, 期 6, 页码 1299-1307出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msp040
关键词
gene regulation; transcription factor; promoter; cis-regulatory element
资金
- Swedish National Research School in Genomics and Bioinformatics
- Gothenburg Stochastic Centre
- Gothenburg Mathematical Modeling Centre
Transcription factors govern gene expression by binding to short DNA sequences called cis-regulatory elements. These sequences are typically located in promoters, which are regions of variable length upstream of the open reading frames of genes. Here, we report that promoter length and gene function are related in yeast, fungi, and plants. In particular, the promoters for stress-responsive genes are in general longer than those of other genes. Essential genes have, on the other hand, relatively short promoters. We utilize these findings in a novel method for identifying relevant cis-regulatory elements in a set of coexpressed genes. The method is shown to generate more accurate results and fewer false positives compared with other common procedures. Our results suggest that genes with complex transcriptional regulation tend to have longer promoters than genes responding to few signals. This phenomenon is present in all investigated species, indicating that evolution adjust promoter length according to gene function. Identification of cis-regulatory elements in Saccharomyces cerevisiae can be done with the web service located at http://enricher.zool.gu.sek.
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