期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 26, 期 11, 页码 2595-2603出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msp175
关键词
theoretical populations genetics; K-a/K-s Moran model; distribution of fitness effects; divergence date
资金
- University of Arizona
- National Institute of Health [GM-076041]
- Alfred P. Sloan Research fellow
Recent empirical studies of taxa including humans, fish, and birds have shown elevated rates of molecular evolution between species that diverged recently. Using the Moran model, we calculate expected divergence as it function of time. Our findings suggest that the observed phenomenon of elevated rates at short timescales is consistent with standard population genetics theory. The apparent acceleration of the molecular clock at short timescales can be explained by segregating polymorphisms present at the time of the ancestral population, both neutral and slightly deleterious, and not newly arising slightly deleterious mutations its has been previously hypothesized. Our work also suggests that the duration of the rate elevation depends oil the effective population size. providing a method to correct time estimates of recent divergence events. Our model concords with estimates of divergence obtained from African cichlid fish and humans. As an additional application of our model, we calculate that K-a/K-s is elevated within a Population before decaying slowly to its long-term value. Similar to the molecular Clock, the duration and magnitude of K-a/K-s elevation depend on the effective population size. Unlike the molecular clock, however, K-a/K-s elevation is caused by newly arising,slightly deleterious mutations. This elevation, although not Lis severe in magnitude as had been previously predicted in models neglecting ancestral polymorphism, persists slightly longer.
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