期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 26, 期 9, 页码 1949-1961出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msp107
关键词
adaptation; transposable elements; Drosophila; purifying selection; life-history traits
资金
- National Institutes of Health [GM077368]
- National Science Foundation [0317171]
- Division Of Environmental Biology
- Direct For Biological Sciences [0317171] Funding Source: National Science Foundation
A recent genomewide screen identified 13 transposable elements that are likely to have been adaptive during or after the spread of Drosophila melanogaster out of Africa. One of these insertions, Bari-Juvenile hormone epoxy hydrolase (Bari-Jheh), was associated with the selective sweep of its flanking neutral variation and with reduction of expression of one of its neighboring genes: Jheh3. Here, we provide further evidence that Bari-Jheh insertion is adaptive. We delimit the extent of the selective sweep and show that Bari-Jheh is the only mutation linked to the sweep. Bari-Jheh also lowers the expression of its other flanking gene, Jheh2. Subtle consequences of Bari-Jheh insertion on life-history traits are consistent with the effects of reduced expression of the Jheh genes. Finally, we analyze molecular evolution of Jheh genes in both the long- and the short-term and conclude that Bari-Jheh appears to be a very rare adaptive event in the history of these genes. We discuss the implications of these findings for the detection and understanding of adaptation.
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