期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 26, 期 8, 页码 1889-1900出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msp101
关键词
evolution; primates; centromere
资金
- MIUR (Ministero Italiano della Universita' e della Ricerca [488/92]
- European Commission [QLRI- CT2002- 01325]
- Howard Hughes Medical Institute [R01 GM058815]
All these data shed light on the evolution of the centromeric sequences in Primates. Our results suggest radical differences in the structure, organization, and evolution of alpha-satellite DNA among different primate species, supporting the notion that 1) all the centromeric sequence in Primates evolved by genomic amplification, unequal crossover, and sequence homogenization using a 171 bp monomer as the basic seeding unit and 2) centromeric function is linked to relatively short repeated elements, more than higher-order structure. Moreover, our data indicate that complex higher-order repeat structures are a peculiarity of the hominid lineage, showing the more complex organization in humans.
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