期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 25, 期 12, 页码 2615-2626出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msn209
关键词
-
The ancestral selection graph, conditioned on the allelic types in the sample, is used to obtain a limiting gene genealogical process under strong selection. In an equilibrium, two-allele system with strong selection, neutral gene genealogies are predicted for random samples and for samples containing at most one unfavorable allele. Samples containing more than one unfavorable allele have gene genealogies that differ greatly from neutral predictions. However, they are related to neutral gene genealogies via the well-known Ewens sampling formula. Simulations show rapid convergence to limiting analytical predictions as the strength of selection increases. These results extend the idea of a soft selective sweep to deleterious alleles and have implications for the interpretation of polymorphism among disease-causing alleles in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据