期刊
SCIENCE
卷 349, 期 6246, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1254766
关键词
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资金
- Princeton University
- W.M. Keck Foundation
- David and Lucile Packard Foundation
- Burroughs Wellcome Foundation
- Defense Advanced Research Projects Agency [HR0011-12-C-0067]
- Program for Breakthrough Biomedical Research
- NIH [OD007290, AI101018, GM081879, DK101674]
Developments in the use of genomics to guide natural product discovery and a recent emphasis on understanding the molecular mechanisms of microbiota-host interactions have converged on the discovery of small molecules from the human microbiome. Here, we review what is known about small molecules produced by the human microbiota. Numerous molecules representing each of the major metabolite classes have been found that have a variety of biological activities, including immune modulation and antibiosis. We discuss technologies that will affect how microbiota-derived molecules are discovered in the future and consider the challenges inherent in finding specific molecules that are critical for driving microbe-host and microbe-microbe interactions and understanding their biological relevance.
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