期刊
MOLECULAR BIOLOGY
卷 47, 期 6, 页码 796-802出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S002689331306006X
关键词
SAGA complex; transcription; mRNA export; mRNP; acetylation; Gcn5; deubiquitinating module (DUBm); ENY2/Sus1; Sgf11; SCA7
资金
- Russian Foundation for Basic Research [13-04-00368, 13-04-00635, 11-04-91339-NNIO_a]
- Program of the Presidium of the Russian Academy of Sciences Molecular and Cell Biology
Eukaryotic gene expression is a multistep process of high complexity. Transcription is one of the cardinal and tightly regulated phases of gene expression. To provide accurate and precise work of the gene regulation apparatus, including a plethora of modifications of the chromatin structure and nucleosome, dynamic turnover must take place. All transcription steps are under the control of large multiprotein coactivator complexes. In this review, we discuss the evolutionary conservative SAGA complex, which acetylates and deubiquitinates histones during transcription activation and, furthermore, is involved in subsequent stages of mRNP biogenesis and export.
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