期刊
SCIENCE
卷 350, 期 6260, 页码 550-554出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aac8653
关键词
-
资金
- NIH [NS086372, NS080586, NS072031, NS072040, R01 NS 067216]
- Caterina Foundation
- Gatsby Charitable Foundation
Light mechanical stimulation of hairy skin can induce a form of itch known as mechanical itch. This itch sensation is normally suppressed by inputs from mechanoreceptors; however, in many forms of chronic itch, including alloknesis, this gating mechanism is lost. Here we demonstrate that a population of spinal inhibitory interneurons that are defined by the expression of neuropeptide Y::Cre (NPY::Cre) act to gate mechanical itch. Mice in which dorsal NPY::Cre-derived neurons are selectively ablated or silenced develop mechanical itch without an increase in sensitivity to chemical itch or pain. This chronic itch state is histamine-independent and is transmitted independently of neurons that express the gastrin-releasing peptide receptor. Thus, our studies reveal a dedicated spinal cord inhibitory pathway that gates the transmission of mechanical itch.
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