期刊
SCIENCE
卷 348, 期 6231, 页码 242-245出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa3952
关键词
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资金
- Royal Society [RG130105]
- Wellcome Trust [098051, 099769/Z/12/Z]
- NIH [HG002385]
- European Research Council [260372]
- Ministerio de Ciencia e Innovacion [BFU2011-28549]
- BIOBASE GmbH
- Cardiff University
- European Research Council (ERC) [260372] Funding Source: European Research Council (ERC)
- Wellcome Trust [099769/Z/12/Z] Funding Source: Wellcome Trust
Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival.
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