期刊
MOLECULAR ASPECTS OF MEDICINE
卷 39, 期 -, 页码 33-49出版社
ELSEVIER
DOI: 10.1016/j.mam.2013.10.003
关键词
Melanoma; Cancer stem cell; ABCB5; Vasculogenic mimicry; Immune evasion; Drug resistance; Therapy
资金
- NIH/NCI [R01CA113796, R01CA158467, R01CA138231, P50CA093683]
- Department of Veterans Affairs VA Merit Review Awards [VA BLRD 1I01BX000516, VA RRD 1I01RX000989]
Melanoma stem cells, also known as malignant melanoma-initiating cells, are identifiable through expression of specific biomarkers such as ABCB5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5), NGFR (nerve growth factor receptor, CD271) and ALDH (aldehyde dehydrogenase), and drive melanoma initiation and progression based on prolonged self-renewal capacity, vasculogenic differentiation and immune evasion. As we will review here, specific roles of these aggressive subpopulations have been documented in tumorigenic growth, metastatic dissemination, therapeutic resistance, and malignant recurrence. Moreover, recent findings have provided pre-clinical proof-of-concept for the potential therapeutic utility of the melanoma stem cell concept. Therefore, melanoma stem cell-directed therapeutic approaches represent promising novel strategies to improve therapy of this arguably most virulent human cancer. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据