期刊
MOLECULAR ASPECTS OF MEDICINE
卷 34, 期 2-3, 页码 548-560出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2012.05.008
关键词
SLC30A; ZnT; Zinc transporter; Zinc homeostasis; Lethal milk; Diabetes
资金
- Swiss National Science Foundation through the National Center of Competence in Research (NCCR) TransCure, University of Bern, Switzerland
- United States Department of Agriculture, ARS [5306-515-30-016-00D, 5306-515-20-006-00D]
Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, Zinc(Zn2+)-Iron(Fe2+) Permease). The two zinc transporter family members function in opposite directions to maintain cellular zinc homeostasis. ZnT proteins contribute to the cytoplasmic zinc balance by exporting zinc out to the extracellular space or by sequestrating cytoplasmic zinc into intracellular compartments when cellular zinc levels are elevated. In contrast, ZIP proteins function to increase cytoplasmic zinc concentrations when cellular zinc is depleted. Since the cloning of the first zinc transporter (ZnT1) in 1995, there have been many advances in zinc transporter research including discovery of new members of zinc transporters, identification of gene expression patterns and regulations, recognition of protein distribution patterns in tissues and cells, and understanding of their physiological and pathological roles in humans and animal models. Ten members of the ZnT family have been identified so far. Here we give a review of these advances and discuss the pathological implications and future preventive or therapeutic applications of ZnTs. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据