期刊
MOLECULAR ASPECTS OF MEDICINE
卷 34, 期 6, 页码 1088-1108出版社
ELSEVIER
DOI: 10.1016/j.mam.2013.02.002
关键词
ADP-ribosylation; DNA repair; Glycohydrolase; Macro domain; Signaling pathways; Transferase
资金
- American Cancer Society
- NIH
- Swedish Foundation for Strategic Research
- Swedish Research Council
- Swedish Cancer Society
- Structural Genomics Consortium
ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation. (C) 2013 Elsevier Ltd. All rights reserved.
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