期刊
MOLECULAR ASPECTS OF MEDICINE
卷 30, 期 3, 页码 111-122出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2009.02.005
关键词
7-Ketocholesterol; 24(S),25-Epoxycholesterol; Efflux; LXR; Oxidised LDL; SREBP
资金
- National Health and Medical Council of Australia
- National Heart Foundation of Australia
Oxysterols are structurally identical to cholesterol, but with one or more additional oxygen containing functional groups (such as alcohol, carbonyl or epoxide groups). The wide array of oxysterols encountered in human health and disease vary in their origin (either enzymic or non-enzymic), and their putative effects and/or function(s). Some are thought to be damaging, whereas others may play important physiological roles, including in the regulation of cholesterol homeostasis. In this review, we will concentrate on the major cellular oxysterols. We summarise their location, generation, metabolism and elimination, as well as providing insights into the latest research into their regulatory roles in cholesterol homeostasis. (C) 2009 Elsevier Ltd. All rights reserved.
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