期刊
MOLECULAR ASPECTS OF MEDICINE
卷 30, 期 6, 页码 406-412出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2009.08.007
关键词
Anthrax toxin; Receptors; Endocytosis; LRP6; ARAP3
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072645, R01AI076852] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI072645, R01 AI072645-02, R01 AI076852] Funding Source: Medline
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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