期刊
MOLECULAR AND CELLULAR PROBES
卷 28, 期 5-6, 页码 242-245出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.mcp.2014.05.001
关键词
Autism; RBFOX1 gene; Gene expression; Lymphocytes; Lymphoblastoid cell lines
类别
资金
- SmithKline Foundation
- University of Verona
- Italian Ministry of Education
- University and Research
Several lines of evidence suggest that RBFOX1 is a key regulator of transcriptional and splicing programs in neural cells during development, and that it is expressed in a neuronal module enriched for known autism susceptibility genes. We have investigated its expression by semiquantitative RT-PCR in accessible nonbrain resources in eighteen autism spectrum disorder sib-pairs belonging to the Italian Autism Network cohort. RBFOX1 gene expression was detected in lymphoblastoid cell lines but not in lymphocytes. No significant differences between autism spectrum disorders and non-affected brothers were found. We were not able to replicate in lymphoblastoid cell lines the previously reported RBFOXI gene downregulation in autism, even if a trend was observed. This might be due to less pronounced transcription level differences in RBFOX1 gene expression in lymphoblastoid cell lines than in brain samples. (C) 2014 Elsevier Ltd. All rights reserved.
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