期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 47, 期 3, 页码 215-222出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2011.04.007
关键词
Motor neuron; V2 interneuron; Cranial ganglia; Cell death; Isl1; Axon growth
资金
- American Heart Association [0865143F]
- National Natural Science Foundation of China [NSFC 31071280]
- Ministry of Science and Technology, China [2011CB504006]
- Shanghai Science and Technology Commission [10PJ1408600]
- Korean Government (MEST) [NRF-2008-313-E00343]
- [NIH5R01HL070867-04]
- National Research Foundation of Korea [2009-0070938, 313-2008-2-E00343] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1 Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons. (C) 2011 Elsevier Inc. All rights reserved.
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