期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 48, 期 4, 页码 349-358出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2011.05.004
关键词
Neuronal development; Migration; Differentiation; Neuronal polarization; Neuropsychiatric disease; Centrosome; Acentrosomal microtubule organization; Microtubule
资金
- Netherlands Organization for Scientific Research (NWO-ALW-VICI)
- Netherlands Organization for Scientific Research (NWO-CW-ECHO)
- Netherlands Organization for Health Research and Development (ZonMW-VIDI)
- Netherlands Organization for Health Research and Development (ZonMW-TOP)
- European Science Foundation (ESF-EURYI)
- European Molecular Biology Organization (EMBO)
- Human Frontier Science Program (HFSP-CDA)
The formation of complex nervous systems requires processes that coordinate proliferation, migration and differentiation of neuronal cells. The remarkable morphological transformations of neurons as they migrate, extend axons and dendrites and establish synaptic connections, imply a strictly regulated process of structural organization and dynamic remodeling of the cytoskeleton. The centrosome serves as the main cytoskeleton-organizing center in the cell and is the classical site of microtubule nucleation and anchoring. Mutations in genes encoding centrosomal proteins cause severe neurodevelopmental disorders that lead to several neuropsychiatric diseases, such as lissencephaly, microcephaly and schizophrenia. While the centrosome has been considered crucial for coordinating neuronal migration and polarization, accumulating experimental findings seems to rule out a central role for the centrosome at later stages of neuronal development. Here, we will review these observations and discuss the importance of centrosomal and acentrosomal microtubule organization for neuronal development. This article is part of a Special Issue entitled 'Neuronal Function'. (C) 2011 Elsevier Inc. All rights reserved.
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