期刊
SCIENCE
卷 347, 期 6218, 页码 159-163出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1260318
关键词
-
资金
- Fondation Bertarelli
- International Paraplegic Foundation
- European Research Council [ERG 259419 ESKIN, ERG 261247 Walk-Again]
- Nano-tera.ch [20NA_145923 SpineRepair]
- Swiss National Science Foundation through the National Centre of Competence in Research (NCCR) in Robotics
- European Commission's Seven Framework Program [CP-IP 258654 NeuWalk]
- National Science Foundation, Materials Research Science and Engineering Center [DMR-0820484]
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据