期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 44, 期 1, 页码 78-93出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2010.02.005
关键词
Neurite outgrowth; Cadherin; Retina; Chick; Axon guidance; Protein tyrosine phosphatase; Cell-cell adhesion
资金
- National Institute of Health [RO1-EY12251]
- Visual Sciences Training [T32-EY007157]
- National Eye Institute [PO-EY11373]
Classical cadherins play distinct roles in axon growth and guidance in the visual system, however, the signaling pathways they activate remain unclear. Growth cones on each cadherin substrate have a unique morphology suggesting that distinct signals are activated by neurite outgrowth on E-, N-, and R-cadherin. We previously demonstrated that receptor protein tyrosine phosphatase-mu (PTPmu) is required for E- and N-cadherin-dependent neurite outgrowth. In this manuscript, we demonstrate that PTPmu regulates R-cadherin-mediated neurite outgrowth. Furthermore, we evaluated whether known PTPmu-associated signaling proteins, Rac1, Cdc42, IQGAP1 and PKC delta, regulate neurite outgrowth mediated by these cadherins. While Rac1 activity is required for neurite outgrowth on all three cadherins Cdc42/IQGAP1 are required only for N- and R-cadherin-mediated neurite outgrowth. In addition, we determined that PKC activity is required for E- and R-cadherin-mediated, but not N-cadherin-mediated neurite outgrowth. In summary, distinct PTP mu-associated signaling proteins are required to promote neurite outgrowth on cadherins. (C) 2010 Elsevier Inc. All rights reserved.
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