期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 38, 期 1, 页码 80-88出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2008.01.017
关键词
schwarm cell; proliferation; cyclin D1; Wallerian degeneration; apoptosis; functional recovery
资金
- NINDS NIH HHS [R01 NS045939-04, R01 NS045939, R01-NS45939-01] Funding Source: Medline
Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve stumps. To resolve the role of Schwann cell proliferation during functional recovery of the injured nerves, we used a mouse model in which injury-induced Schwarnn cell mitotic response is ablated via targeted disruption of cyclin D1. In the absence of distal Schwann cell proliferation, axonal regeneration and myelination occur normally in the mutant mice and functional recovery of injured nerves is achieved. This is enabled by pre-existing Schwann cells in the distal stump that persist but do not divide. On the other hand, in the wild type littermates, newly generated Schwann cells of injured nerves are culled by apoptosis. As a result, distal Schwann cell numbers in wild type and cyclin D1 null mice converge to equivalence in regenerated nerves. Therefore, distal Schwann cell proliferation is not required for functional recovery of injured nerves. (C) 2008 Elsevier Inc. All rights reserved.
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