期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 37, 期 2, 页码 412-424出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2007.10.018
关键词
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资金
- NINDS NIH HHS [P30 NS047463-039003, P30 NS047463-029003, R01 NS045883-04, P30 NS047463, P30 NS047463-049003, P30 NS047463-059003, P30 NS047463-019003, R01 NS045883-02, R01 NS045883-03, R01 NS045883-01A1S1, R01 NS045883-01A1, R01 NS045883, 5P30NS047463] Funding Source: Medline
Development of a complex process network by maturing oligodendrocytes is a critical but currently poorly characterized step toward myelination. Here, we demonstrate that the matricellular oligodendrocyte-derived protein phosphodiesterase-I alpha/autotaxin (PD-I alpha/ATX) and especially its MORFO domain are able to promote this developmental step. In particular, the single EF hand-like motif located within PD-I alpha/ATX's MORFO domain was found to stimulate the outgrowth of higher order branches but not process elongation. This motif was also observed to be critical for the stimulatory effect of PD-I alpha/ATX's MORFO domain on the reorganization of focal adhesions located at the leading edge of oligodendroglial protrusions. Collectively, our data suggest that PD-I alpha/ATX promotes oligodendroglial process network formation and expansion via the cooperative action of multiple functional sites located within the MORFO domain and more specifically, a novel signaling pathway mediated by the single EF hand-like motif and regulating the correlated events of process outgrowth and focal adhesion organization. (C) 2007 Elsevier Inc. All rights reserved.
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