期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 391, 期 1-2, 页码 41-49出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2014.04.013
关键词
MicroRNA; Metabolic syndrome; Diabetes; MRNA expression; NMR metabolomics
资金
- European Union 7th Framework Programme [201668]
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Tampere Tuberculosis Foundation, the Emil Aaltonen Foundation
- Tampere University Hospital Medical Fund [9N035, X51001]
- Academy of Finland
- TEKES - the Finnish Funding Agency for Technology and Innovation (MAK)
- Sigrid Juselius Foundation (MAK)
- Strategic Research Funding from the University of Oulu
- Foundation of Clinical Chemistry
- Aarne Koskelo Foundation
- Tampere City Science Foundation
- Alfred Kordelin Foundation
- MRC [MC_UU_12013/1] Funding Source: UKRI
- Medical Research Council [MC_UU_12013/1] Funding Source: researchfish
Since metabolic syndrome (MetS) is a collection of cardiovascular risk factors involving multiple signaling systems, we related the metabolic abnormalities associated with MetS with circulating microRNA profiles to pinpoint the affected signaling pathways. The blood microRNA profile, genome wide gene expression and serum NMR metabolomics were analyzed from 71 participants of the Young Finns Study. We found nine microRNAs that associated significantly with metabolites connected to MetS. MicroRNA-144-5p concentration correlated with glucose levels, hsa-1207-5p with glycosylated hemoglobin and hsa-miR-484 with metabolites related to insulin resistance. Hsa-miR-625-3p correlated with cholesterol levels, hsa-miR-1237-3p and hsa-miR-331-3p expression with certain fatty acids levels and hsa-miR-129-1-3p, -129-2-3p, and -1288-3p with glycerol levels. The down-regulated targets of miR-1207-5p and -129-2-3p were enriched in PI3K and MAPK pathways and 8 out of the 12 enriched pathways were down-regulated in individuals with MetS. In conclusion microRNAs associated with several aspects of MetS, possibly regulating glucose and lipid metabolism. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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