期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 380, 期 1-2, 页码 41-54出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.12.014
关键词
Glucocorticoids; Glucocorticoid receptor; Transactivation; Transrepression; Cross-talk; Transcription factor
资金
- strategic basic research grant from IWT-Vlaanderen
- NOI (nieuwe onderzoeksinitiatieven) research grant from the University of Antwerp
- Methusalem grant of the University of Gent
The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically triggered by glucocorticoid hormones. Apart from driving gene transcription via binding onto glucocorticoid response elements in regulatory regions of particular target genes, GR can also inhibit gene expression via transrepression, a mechanism largely based on protein:protein interactions. Hereby GR can influence the activity of other transcription factors, without contacting DNA itself. GR is known to inhibit the activity of a growing list of immune-regulating transcription factors. Hence, GCs still rule the clinic for treatments of inflammatory disorders, notwithstanding concomitant deleterious side effects. Although patience is a virtue when it comes to deciphering the many mechanisms GR uses to influence various signaling pathways, the current review is testimony of the fact that groundbreaking mechanistic work has been accumulating over the past years and steadily continues to grow. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据