期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 369, 期 1-2, 页码 1-14出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2013.01.025
关键词
Gene expression; Gonad maturation; Brain; qPCR; Screening; Sequence
资金
- European Community's 7th Framework Program under the Theme 2 Food, Agriculture and Fisheries, and Biotechnology [245257]
- Generalitat Valenciana [ACOMP/2012/086]
- UPV [CEI-01-10, PAID-00-11, PTA2011-4948-I]
- Research Council of Norway (EJ/hsm IS-STP)
- MICINN
- Spanish Ministry of Science and Innovation (MICINN)
- Generalitat Valenciana
- UPV PAID Programme [2011-S2-02-6521]
- Norwegian School of Veterinary Science
Gonadotropin-releasing hormone receptor (GnRH-R) activation stimulates synthesis and release of gonadotropins in the vertebrate pituitary and also mediates other processes both in the brain and in peripheral tissues. To better understand the differential function of multiple GnRH-R paralogs, three GnRH-R genes (gnrhr1a, 1b, and 2) were isolated and characterized in the European eel. All three gnrhr genes were expressed in the brain and pituitary of pre-pubertal eels, and also in several peripheral tissues, notably gills and kidneys. During hormonally induced sexual maturation, pituitary expression of gnrhr1a (female) and gnrhr2 (male and female) was up-regulated in parallel with gonad development. In the brain, a clear regulation during maturation was seen only for gnrhr2 in the midbrain, with highest levels recorded during early vitellogenesis. These data suggest that GnRH-R2 is the likely hypophysiotropic GnRH-R in male eel, while both GnRH-R1a and GnRH-R2 seems to play this role in female eels. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
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