期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 360, 期 1-2, 页码 3-13出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.09.046
关键词
Castration resistant; Androgen receptor; Splice variant; Steroidogenesis; Intracrine; Steroid transport
资金
- Pacific Northwest Prostate Cancer SPORE [P50 CA97186]
- Prostate Cancer Foundation
- Damon Runyon Cancer Research Foundation [CI-40-08]
The transcriptional programs regulated through the activity of the androgen receptor (AR) modulate normal prostate development and the maintenance of prostatic functions at maturity. AR signaling also controls key survival and growth functions operative in prostate cancer. Inhibiting the AR program remains the key target in the treatment of advanced prostate cancer, and suppressing AR also holds great potential for preventing the development or progression of early stage prostate cancer. In this review, we detail molecular mechanisms of AR activity, cellular components contributing to the maintenance of AR signaling despite AR-ligand suppression, and discuss treatment strategies designed to target components of resistance to AR-directed therapeutics. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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