期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 349, 期 1, 页码 45-50出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.05.008
关键词
Circadian; Clock gene; Adipose; Adipocyte; Metabolism; Translational
资金
- UK Biotechnology and Biological Sciences Research Council (BBSRC) [BB/D526853/1]
- Diabetes-UK [08/0003 607]
- Stockgrand UK Ltd.
- Biotechnology and Biological Sciences Research Council [BB/I008470/1] Funding Source: researchfish
- BBSRC [BB/I008470/1, BB/D526853/1] Funding Source: UKRI
Emerging links between circadian rhythms and metabolism promise much for the understanding of metabolic physiology and pathophysiology, in which white adipose tissue (WAT) plays a prominent role. Many WAT endocrine molecules, termed adipokines, display rhythmic plasma concentration. Moreover, similar to most other tissues, WAT exhibits widespread 24-h variation in gene expression, with approximately 20% of the murine adipose transcriptome estimated to undergo daily variation. A major limitation to human chronobiology research is the availability of physiologically defined peripheral tissues. To date most analyses of in vivo human peripheral clocks has been limited to blood leucocytes. However, subcutaneous adipose tissue represents a novel opportunity to study peripheral molecular rhythms that are of clearly defined metabolic relevance. This review summarises basic concepts of circadian and metabolic physiology before then comparing alternative protocols used to analyse the rhythmic properties of human adipose tissue. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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