期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 358, 期 2, 页码 146-154出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.08.022
关键词
Steroidogenesis; Pre-receptor regulation; Estrogen receptor; Coregulator; Hydroxysteroid (17beta) dehydrogenase; Aromatase
Endometriosis is an estrogen-dependent gynecological disease where endometrium-like tissue grows outside uterine cavity. Endometriotic cell proliferation is stimulated by estrogens acting predominantly via their nuclear receptors. Estrogen receptors (ESR1, ESR2) are ligand activated transcription factors whose activation is dependent on the cell-specific dynamic expression of the receptors, on the interacting proteins and on the ligand availability. The different types of endometriotic lesions, peritoneal, deep, and ovarian endometriosis, may respond to estrogens differentially due to differences in the expression of the receptors and interacting proteins, and due to potential differences in the ligand availability regulated by the local estrogen synthesis. This review summarizes the current knowledge of estrogen synthesizing enzymes and estrogen receptors in different types of endometriosis lesions. Further studies are still needed to define the possible differences in steroid metabolism in different types of endometriotic lesions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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