期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 364, 期 1-2, 页码 126-133出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.08.016
关键词
Breast; Cancer; Estrogen; Adhesion; Desmosome
资金
- Ligue Regionale de Lutte contre le Cancer
- Association pour la Recherche contre le Cancer [SFI2010-1201906]
- BQR Grants from University of Montpellier 1
The association of estrogen receptor alpha (ER alpha) expression with differentiated breast tumors presenting a lower metastasis risk could be explained by the estrogen modulation of cell adhesion, motility and invasiveness. Since desmosomes play a crucial role in cell-cell adhesion and may interfere in tumor progression, we studied their regulation by estrogens in human breast cancer and normal mammary cells. Estrogens increased the formation of desmosomes in normal and malignant cells. Furthermore, four desmosomal proteins (desmocollin, gamma-catenin, plakophilin and desmoplakin) appeared significantly up-regulated by estrogens in three ER alpha-expressing cancer cell lines and this effect was reversed by a pure antiestrogen. Finally, silencing of ER alpha or desmoplakin expression by specific siRNA revealed that estrogen-modulated desmosomal proteins are essential for the estrogenic control of intercellular adhesion. This estrogen modulation of desmosome formation could contribute to the lower invasiveness of ER alpha-positive tumors and to the integrity of epithelial layers in estrogen target tissues. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据