期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 353, 期 1-2, 页码 68-74出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.10.023
关键词
PtdIns(4,5)P-2; PIP2; TRP channel; TRPM8; Temperature sensation
资金
- National Institutes of Health [NS055159, GM093290]
- UMDNJ Foundation
Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca2+ permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a well established sensor of environmental cold temperatures, found in peripheral sensory neurons, where its activation evokes depolarization and action potentials. The activity of TRPM8 is regulated by a number of cellular signaling pathways, most notably by phosphoinositides and the activation of phospholipase C. This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据