期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 354, 期 1-2, 页码 16-21出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.10.008
关键词
Uterus; Lactocrine; Colostrum; Development; Endocrine disruption; Maternal environment
资金
- National Research Initiative Competitive Grant [2007-35203-18098]
- NSF-EPS [0814103]
- EPSCoR
- Office Of The Director [0814103] Funding Source: National Science Foundation
For eutherian mammals a continuum of maternal support insures that development of progeny follows an optimal program. Beginning in utero, such support extends into the early neonatal period when bioactive factors are communicated from mother to offspring in colostrum/milk. Defined as lactocrine signaling, communication of milk-borne bioactive factors from mother to offspring as a consequence of nursing is important for development of somatic tissues, including the female reproductive tract (FRT). Data for the domestic pig indicate that lactocrine signaling contributes to the maternal continuum of factors that define the developmental program and determine the developmental trajectory of FRT tissues during early neonatal life. Both naturally occurring and manmade factors of environmental origin can be communicated to neonates in milk and affect development with lasting consequences. Here, evidence for lactocrine programming of FRT development and the potential for environmental endocrine disruption of this process are reviewed. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据