期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 356, 期 1-2, 页码 48-54出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.07.051
关键词
Activin A; Follistatin; Human small antral follicles; Granulosa cells; Follicular fluid
资金
- Danish Cancer Society [DP05112/R2-A41-09-S2]
- Danish Medican Research Council [271-07-0452, 09-072265]
- Novo Nordic Foundation
- Sophus Carl Emil Friis and wife Olga Doris Friis foundation
- Lundbeck foundation
- University Hospital of Copenhagen
The present study correlated concentrations of activin A and follistatin in follicular fluid (FF) from human small antral follicles to FF concentrations of AMH, inhibin B, progesterone, and oestradiol and to the mRNA expression of FSH-receptor (FSHR), LH-receptor (LHR), AMH-receptor2 (AMHR2), CYP19a, and androgen-receptor (AR) in the corresponding granulosa cells (GC). FF from 144 follicles (3-12 mm in diameter) was included whereas mRNA expression profiles were established in GC from 66 of the 144 follicles. Levels of follistatin remained constant in relation to follicular diameter, whereas activin A levels increased in follicles exceeding 10 mm in diameter. Levels of activin A and inhibin B showed a highly significant inverse association. Follistatin showed highly significant positive associations with AMH and inhibin B levels and with FSHR and AR gene expression in GC. This study revealed unexpected associations that probably reflect the complicated regulatory mechanisms governing human folliculogenesis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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