期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 361, 期 1-2, 页码 191-201出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.04.010
关键词
Progesterone receptor; Breast lineage; Estrogen receptor; Progenitor
资金
- National Health and Medical Research Council of Australia (NHMRC)
- Cancer Institute New South Wales
- NHMRC [512406]
- National Breast Cancer Foundation [PF-12-08] Funding Source: researchfish
Progesterone is critical in normal breast development and its synthetic derivatives are emerging as major drivers of breast cancer risk. The recent demonstration that progesterone regulates the stem cell compartment in the murine mammary gland, despite the absence of progesterone receptor (PR) in mammary stem cells, highlights the fact that PR distribution in progenitor cell subsets in the human breast remains to be conclusively shown. By utilising two independent cell sorting strategies to fractionate cells into distinct subpopulations enriched for different cell lineage characteristics, we have demonstrated a consistent enrichment of PR transcripts, relative to estrogen receptor transcripts, in the bipotent progenitor subfraction in the normal human breast. We have also shown co-expression of both steroid hormone receptors with basal markers in a subset of human breast cells, and finally we have demonstrated that PR+ bipotent progenitor cells are estrogen-insensitive, and that estrogen regulates PR in mature luminal cells only. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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