期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 336, 期 1-2, 页码 70-79出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.12.007
关键词
Mitochondria; Protein import; Steroidogenesis; Cholesterol transport; Translocator protein; Steroidogenic acute regulatory protein
资金
- CIHR [MOP102647, TGF36110] Funding Source: Medline
- NIEHS NIH HHS [R01 ES07747, R01 ES007747, R01 ES007747-16, R01 ES007747-15] Funding Source: Medline
The principal site of regulation of steroid hormone biosynthesis is the transfer of cholesterol from the outer to inner mitochondrial membrane. Hormonal stimulation of steroidogenic cells promotes this mitochondrial lipid import through a multi-protein complex, termed the transduceosome, spanning the two membranes. The transduceosome complex is assembled from multiple proteins, such as the steroidogenic acute regulatory (STAR) protein and translocator protein (TSPO), and requires their targeting to the mitochondria for transduceosome function. The vast majority of mitochondrial proteins, including those participating in cholesterol import, are encoded in the nucleus. Their subsequent mitochondrial incorporation is performed through a series of protein import machineries located in the outer and inner mitochondrial membranes. Here we review our current knowledge of the mitochondrial cholesterol import machinery of the transduceosome. This is complemented with descriptions of mitochondrial protein import machineries and mechanisms by which these machineries assemble the transduceosome in steroidogenic mitochondria. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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