期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 339, 期 1-2, 页码 130-135出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.04.005
关键词
Growth factors; Hybrid receptors; Receptor activation; DNA synthesis; Glucose metabolism
资金
- Landstinget Ostergotland, Barndiabetesfonden
- Swedish Research Council
We compared insulin and IGF effects in adipocytes expressing IR (insulin receptors), and preadipocytes expressing IR and IGF-IR (IGF-I receptors). Treatment of adipocytes with insulin, IGF-II or IGF-I resulted in phosphorylation of IR. Order of potency was insulin >IGF-II> IGF-I. In preadipocytes IR, IGF-IR and insulin/IGF-I hybrid receptors (HR) were detected. Treatment of preadipocytes with IGF-I and IGF-II 10(-8) M resulted in activation of IGF-IR and IR whereas insulin was more potent in activating IR, with no effect on IGF-IR. In adipocytes glucose transport was 100-fold more sensitive to insulin than to IGFs and the maximal effect was higher with insulin. In preadipocytes glucose accumulation and DNA synthesis was equally sensitive to insulin and IGFs but the maximal effect was higher with IGF-I. In conclusion, insulin and IGF-I activate their cognate receptors and IGF-I also HR. IGF-II activates IR, IGF-IR and HR. Insulin and IGF-I are partial agonists to each other's receptors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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