期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 332, 期 1-2, 页码 261-270出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.11.002
关键词
Leptin; Resistin; Catecholamines; Adipocytes
资金
- Ministry of Education (Singapore) [T206B3220]
Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through beta-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca2+ dependent pathways. The crosstalks between adipokines and catecholamines were further corroborated by co-culturing 3T3-L1 adipocytes and PC12 cells. Our findings highlight the importance of adipo-adrenal axis in energy metabolism and the intricate interactions between metabolic hormones. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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