期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 324, 期 1-2, 页码 39-44出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.03.011
关键词
Puberty; Endocrine disrupter; Menarche; Environment
资金
- EU [212844]
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Paediatric Research Foundation
Secular trends in timing of puberty appear to continue although under-nutrition has not been any longer a limiting factor for pubertal development. Now obesity and other environmental reasons have been suspected to cause this trend, and endocrine disrupting chemicals have become into focus as possible contributors. Epidemiological studies on endocrine disrupters are still scarce and show only weak associations between exposures and timing of puberty. Since genetic background explains 50-80% of variability in the timing of puberty, it is not surprising that the observed environmental effects are rather modest when individual exposures are assessed. Despite that, some exposures have been reported to be associated to early (e.g., polybrominated biphenyls) or delayed (e.g., lead) puberty. Here we shortly review the available data on recent trends in timing of puberty and the possible role of endocrine disrupters. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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