期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 314, 期 1, 页码 1-16出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.07.031
关键词
Adipokines; Metabolic syndrome; Adipose tissue; Obesity; Inflammation; Adipocytes
资金
- Foundation of Scientific and Medical Research
- General Division of Scientific Research (Belgium)
Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are overproduced with increasing adiposity, while some adipokines with anti-inflammatory or insulin-sensitizing properties, like adiponectin are decreased. This dysregulation of adipokine production may promote obesity-linked metabolic disorders and cardiovascular disease. Besides considering adipokines, this review will also highlight the cellular key players and molecular mechanisms involved in adipose inflammation. Targeting the changes in the cellular composition of adipose tissue, the underlying molecular mechanisms, and the altered production of adipokines may have therapeutic potential in the management of the metabolic syndrome. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据