期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 321, 期 1, 页码 44-49出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.10.009
关键词
NTRK1; Gene rearrangement; Papillary thyroid tumor
资金
- AIRC (Associazione Italiana Ricerca Cancro)
- ACC (Alleanza Contro il Cancro)
- Ministry of Health
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of IRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of IRK oncoproteins. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据