期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 318, 期 1-2, 页码 34-43出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.08.031
关键词
Obesity; Siberian hamster; Denervation; Norepinephrine; Calcitonin gene-related peptide
资金
- National Institutes of Health [R37 DK 35254]
- Center for Behavioral Neuroscience Viral Tract Tracing Core at Georgia State University through the National Science Foundation [IBN-9876754]
Circulating factors are typically invoked to explain bidirectional communication between the CNS and white adipose tissue (WAT). Thus, initiation of lipolysis has been relegated primarily to adrenal medullary secreted catecholamines and the inhibition of lipolysis primarily to pancreatic insulin, whereas signals of body fat levels to the brain have been ascribed to adipokines such as leptin. By contrast, evidence is given for bidirectional communication between brain and WAT occurring via the sympathetic nervous system (SNS) and sensory innervation of this tissue. Using retrograde transneuronal viral tract tracers, the SNS outflow from brain to WAT has been defined. Functionally, sympathetic denervation of WAT blocks lipolysis to a variety of lipolytic stimuli. Using anterograde transneuronal viral tract tracers, the sensory input from WAT to brain has been defined. Functionally, these WAT sensory nerves respond electrophysiologically to increases in WAT SNS drive suggesting a possible neural negative feedback loop to regulate lipolysis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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