期刊
SCIENCE
卷 348, 期 6234, 页码 589-594出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa7017
关键词
-
资金
- NIH [R01 DK060027]
- National Research Foundation of Korea [NRF-2013M3A9B6076413]
- Japan Society for the Promotion of Science
- National Science Foundation
- National Research Foundation of Korea [2013M3A9B6076415] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Aire is an important regulator of immunological tolerance, operating in a minute subset of thymic stromal cells to induce transcripts encoding peptides that guide T cell selection. Expression of Aire during a perinatal age window is necessary and sufficient to prevent the multiorgan autoimmunity characteristic of Aire-deficient mice. We report that Aire promotes the perinatal generation of a distinct compartment of Foxp3(+)CD4(+) regulatory T (T-reg) cells, which stably persists in adult mice. This population has a role in maintaining self-tolerance, a transcriptome and an activation profile distinguishable from those of T-regs produced in adults. Underlying the distinct T-reg populations are age-dependent, Aire-independent differences in the processing and presentation of thymic stromal-cell peptides, resulting in different Tcell receptor repertoires. Our findings expand the notion of a developmentally layered immune system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据