期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 320, 期 1-2, 页码 97-105出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.02.002
关键词
TGF beta; Telomerase; Cell cycle
资金
- National Health and Medical Research Council of Australia
- Australia Research Council
- Cancer Council of Victoria, Australia
Recent studies suggest that transforming growth factor beta (TGF-beta) inhibits telomerase activity by repression of the telomerase reverse transcriptase (TERT) gene. In this report, we show that TGF-beta induces TERT repression-dependent apoptosis in pancreatic tumor, vascular smooth muscle, and cervical cancer cell cultures. TGF-beta activates Smad3 signaling, induces TERT gene repression and results in G1/S phase cell cycle arrest and apoptosis. TERT over-expression stimulates the G1/S phase transition and alienates TGF beta-induced cell cycle arrest and apoptosis. Our data suggest that telomere maintenance is a limiting factor of the transition of the cell cycle. TGF-beta triggers cell cycle arrest and death by a mechanism involving telomerase deregulation of telomere maintenance. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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