期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 326, 期 1-2, 页码 55-59出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.02.012
关键词
Pituitary tumor transforming gene; Pituitary adenomas; Cell cycle; Proliferation; Senescence
资金
- NCI NIH HHS [R01 CA075979-11A1, R01 CA075979] Funding Source: Medline
Despite the high prevalence of pituitary adenomas they are invariably benign, indicative of unique intrinsic mechanisms controlling pituitary cell proliferation. Cellular senescence is characterized by a largely irreversible cell cycle arrest and constitutes a strong anti-proliferative response, which can be triggered by DNA damage, chromosomal instability and aneuploidy, loss of tumor suppressive signaling or oncogene activation. In vivo senescence is an important protective mechanism against cancer. Here we discuss prospective mechanisms underlying senescence-associated molecular pathways activated in benign pituitary adenomas. Both deletion and over-expression of pituitary tumor transforming gene (Pttg) promote chromosomal instability and aneuploidy. Pug deletion abrogates tumor development by activating p53/p21-dependent senescence pathways. Abundant PTTG in GH-secreting pituitary adenomas also triggers p21-dependent senescence. Pituitary p21 may therefore safeguard against further chromosomal instability by constraining pituitary tumor growth. These observations point to senescence as a target for effective therapy for both tumor silencing and growth restraint towards development of pituitary malignancy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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