期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 300, 期 1-2, 页码 7-16出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.10.001
关键词
Glucocorticoid receptor; Glucocorticoid resistance; Hematological malignancy; Alternative initiation of translation
资金
- Intramural NIH HHS [Z01 ES090057-12, Z99 ES999999] Funding Source: Medline
- NHLBI NIH HHS [R01 HL094558] Funding Source: Medline
Glucocorticoid receptor agonists are mainstays in the treatment of various malignancies of hematological origin. Glucocorticoids are included in therapeutic regimens for their ability to stimulate intracellular signal transduction cascades that culminate in alterations in the rate of transcription of genes involved in cell cycle progression and programmed cell death. Unfortunately, subpopulations of patients undergoing systemic glucocorticoid therapy for these diseases are or become insensitive to glucocorticoid-induced cell death, a phenomenon recognized as glucocorticoid resistance. Multiple factors contributing to glucocorticoid resistance have been identified. Here we summarize several of these mechanisms and describe the processes involved in generating a host of glucocorticoid receptor isoforms from one gene, The potential role of glucocorticoid receptor isoforms in determining cellular responsiveness to glucocorticoids is (C) emphasized. 2008 Published by Elsevier Ireland Ltd.
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