期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 299, 期 1, 页码 72-78出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.10.052
关键词
Klotho; beta Klotho; FGF15; FGF19; FGF21; FGF23; Metabolism
The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. It has been shown that Klotho-deficient mice and Fgf23 knockout mice exhibit identical phenotypes. This observation led to the identification of Klotho as a cofactor essential for interactions between FGF23 and FCF receptors. In addition to the Klotho-FGF23 axis, recent studies has shown that beta Klotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21. This review summarizes recent progress in understanding of Klotho and beta Klotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23). (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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