期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 295, 期 1-2, 页码 101-105出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.05.014
关键词
Growth hormone; Lipolysis; Human omental adipose tissue; Hormone-sensitive lipase mRNA; Interferon beta; Dexamethasone
资金
- The Van Vleet Chair of Excellence, University of Tennessee
- Zen-Bio Inc
Growth hormone [GH] administration results in a reduction in adiposity of humans that is attributed to stimulation of lipolysis. We examined the effect of direct addition of human GH, in both the absence and presence of dexamethasone [Dex], as well as that of interferon beta on lipolysis by omental adipose tissue explants from obese women incubated for 48 h in primary culture. There was a significant stimulation of lipolysis by GH in the presence of Dex but not by Dex or GH alone. There was also a significant further stimulation by GH in the presence of Dex of hormone-sensitive lipase, perilipin, lipoprotein lipase and beta 1 adrenergic receptor mRNA. We conclude that the direct lipolytic effect of CH is accompanied by an increase in HSL mRNA in the presence of DEX, but GH also increased the mRNAs for other proteins that could explain all or part of its lipolytic action. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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